Analysis of Fcγ Receptor IIIa and IIa Polymorphisms: Lack of Correlation with Outcome in Trastuzumab-Treated Breast Cancer Patients
Identifieur interne : 000601 ( France/Analysis ); précédent : 000600; suivant : 000602Analysis of Fcγ Receptor IIIa and IIa Polymorphisms: Lack of Correlation with Outcome in Trastuzumab-Treated Breast Cancer Patients
Auteurs : Sara A. Hurvitz [États-Unis] ; David J. Betting [États-Unis] ; Howard M. Stern [États-Unis] ; Emmanuel Quinaux [Belgique] ; Jeremy Stinson [États-Unis] ; Somasekar Seshagiri [États-Unis] ; YING ZHAO [États-Unis] ; Marc Buyse [Belgique] ; John Mackey [Canada] ; Adrian Driga [Canada] ; Sambasivarao Damaraju [Canada] ; Mark X. Sliwkowski [États-Unis] ; Nicholas J. Robert [États-Unis] ; Vicente Valero [États-Unis] ; John Crown [Irlande (pays)] ; Carla Falkson [États-Unis] ; Adam Brufsky [États-Unis] ; Tadeusz Pienkowski [Pologne] ; Wolfgang Eiermann [Allemagne] ; Miguel Martin [Espagne] ; Valerie Bee [France] ; Omkar Marathe [États-Unis] ; Dennis J. Slamon [États-Unis] ; John M. Timmerman [États-Unis]Source :
- Clinical cancer research [ 1078-0432 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Purpose: The mechanisms by which trastuzumab imparts clinical benefit remain incompletely understood. Antibody-dependent cellular cytotoxicity via interactions with Fcγ receptors (FcγR) on leukocytes may contribute to its antitumor effects. Single-nucleotide polymorphisms (SNP) in FCGR3A and FCGR2A genes lead to amino acid substitutions at positions 158 and 131, respectively, and affect binding of antibodies to FcγR such that 158V/V and 131H/H bind with highest affinity. This study aimed to determine whether high-affinity SNPs are associated with disease-free survival (DFS) among patients with HER2-positive nonmetastatic breast cancer. Experimental Design: Genomic DNA was isolated from 1,286 patients enrolled in a trial of adjuvant trastuzumab-based chemotherapy. Genotyping was conducted using Sanger sequencing and Sequenom mass spectrometry. Results: Patient samples (N = 1,189) were successfully genotyped for FCGR3A and 1,218 for FCGR2A. Compared with the overall results of the BCIRG006 study, in the subset of patients genotyped in this analysis, a less robust improvement in DFS was observed for the trastuzumab arms than control arm (HR, 0.842; P = 0.1925). When stratified for prognostic features, the HR in favor of trastuzumab was consistent with that of the overall study (HR, 0.74; P = 0.036). No correlation between DFS and FCGR3A/2A genotypes was seen for trastuzumab-treated patients (158V/V vs. V/F vs. F/F, P = 0.98; 131 H/H vs. H/R vs. R/R, P = 0.76; 158V/V and/or 131H/H vs. others, P = 0.67). Conclusion: This analysis evaluating the association between FCGR3A/2A genotypes and trastuzumab efficacy in HER2-positive breast cancer did not show a correlation between FCGR3A-V/F and FCGR2A-H/R SNPs and DFS in patients treated with trastuzumab.
Affiliations:
- Allemagne, Belgique, Canada, Espagne, France, Irlande (pays), Pologne, États-Unis
- Alabama, Californie, Communauté de Madrid, Pennsylvanie, Texas, Virginie, Île-de-France
- Los Angeles, Madrid, Paris
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Hurvitz</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>University of California at Los Angeles</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Betting, David J" sort="Betting, David J" uniqKey="Betting D" first="David J." last="Betting">David J. Betting</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>University of California at Los Angeles</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Stern, Howard M" sort="Stern, Howard M" uniqKey="Stern H" first="Howard M." last="Stern">Howard M. Stern</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Genentech, South San Francisco</s1><s2>California</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Quinaux, Emmanuel" sort="Quinaux, Emmanuel" uniqKey="Quinaux E" first="Emmanuel" last="Quinaux">Emmanuel Quinaux</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>International Drug Development Institute</s1><s2>Louvain-la-Neuve</s2><s3>BEL</s3><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>International Drug Development Institute</wicri:noRegion></affiliation></author><author><name sortKey="Stinson, Jeremy" sort="Stinson, Jeremy" uniqKey="Stinson J" first="Jeremy" last="Stinson">Jeremy Stinson</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Genentech, South San Francisco</s1><s2>California</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Seshagiri, Somasekar" sort="Seshagiri, Somasekar" uniqKey="Seshagiri S" first="Somasekar" last="Seshagiri">Somasekar Seshagiri</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Genentech, South San Francisco</s1><s2>California</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ying Zhao" sort="Ying Zhao" uniqKey="Ying Zhao" last="Ying Zhao">YING ZHAO</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>University of California at Los Angeles</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Buyse, Marc" sort="Buyse, Marc" uniqKey="Buyse M" first="Marc" last="Buyse">Marc Buyse</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>International Drug Development Institute</s1><s2>Louvain-la-Neuve</s2><s3>BEL</s3><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>International Drug Development Institute</wicri:noRegion></affiliation></author><author><name sortKey="Mackey, John" sort="Mackey, John" uniqKey="Mackey J" first="John" last="Mackey">John Mackey</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Cross Cancer Institute, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Driga, Adrian" sort="Driga, Adrian" uniqKey="Driga A" first="Adrian" last="Driga">Adrian Driga</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Cross Cancer Institute, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Damaraju, Sambasivarao" sort="Damaraju, Sambasivarao" uniqKey="Damaraju S" first="Sambasivarao" last="Damaraju">Sambasivarao Damaraju</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Cross Cancer Institute, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Sliwkowski, Mark X" sort="Sliwkowski, Mark X" uniqKey="Sliwkowski M" first="Mark X." last="Sliwkowski">Mark X. Sliwkowski</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Genentech, South San Francisco</s1><s2>California</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Robert, Nicholas J" sort="Robert, Nicholas J" uniqKey="Robert N" first="Nicholas J." last="Robert">Nicholas J. Robert</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Virginia Cancer Specialists, US Oncology</s1><s2>Fairfax, Virginia</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Valero, Vicente" sort="Valero, Vicente" uniqKey="Valero V" first="Vicente" last="Valero">Vicente Valero</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>University of Texas MD Anderson Cancer Center</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Crown, John" sort="Crown, John" uniqKey="Crown J" first="John" last="Crown">John Crown</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>St. Vincent's Hospital</s1><s2>Dublin</s2><s3>IRL</s3><sZ>15 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>St. Vincent's Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Falkson, Carla" sort="Falkson, Carla" uniqKey="Falkson C" first="Carla" last="Falkson">Carla Falkson</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Uiversity of Alabama at Birmingham</s1><s2>Birmingham, Alabama</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Brufsky, Adam" sort="Brufsky, Adam" uniqKey="Brufsky A" first="Adam" last="Brufsky">Adam Brufsky</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>University of Pittsburgh Medical Center</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Pienkowski, Tadeusz" sort="Pienkowski, Tadeusz" uniqKey="Pienkowski T" first="Tadeusz" last="Pienkowski">Tadeusz Pienkowski</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Cancer Center</s1><s2>Warsaw</s2><s3>POL</s3><sZ>18 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Cancer Center</wicri:noRegion></affiliation></author><author><name sortKey="Eiermann, Wolfgang" sort="Eiermann, Wolfgang" uniqKey="Eiermann W" first="Wolfgang" last="Eiermann">Wolfgang Eiermann</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Redcross Women's Hospital</s1><s2>Muenchen</s2><s3>DEU</s3><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Muenchen</wicri:noRegion><wicri:noRegion>Redcross Women's Hospital</wicri:noRegion><wicri:noRegion>Redcross Women's Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Miguel" sort="Martin, Miguel" uniqKey="Martin M" first="Miguel" last="Martin">Miguel Martin</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Hospital Gregorio Maranon</s1><s2>Madrid</s2><s3>ESP</s3><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bee, Valerie" sort="Bee, Valerie" uniqKey="Bee V" first="Valerie" last="Bee">Valerie Bee</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Breast Cancer International Research Group (BCIRG)</s1><s2>Paris</s2><s3>FRA</s3><sZ>21 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Marathe, Omkar" sort="Marathe, Omkar" uniqKey="Marathe O" first="Omkar" last="Marathe">Omkar Marathe</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>University of California at Los Angeles</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Slamon, Dennis J" sort="Slamon, Dennis J" uniqKey="Slamon D" first="Dennis J." last="Slamon">Dennis J. Slamon</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>University of California at Los Angeles</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Timmerman, John M" sort="Timmerman, John M" uniqKey="Timmerman J" first="John M." last="Timmerman">John M. Timmerman</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>University of California at Los Angeles</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Clinical cancer research</title><title level="j" type="abbreviated">Clin. cancer res.</title><idno type="ISSN">1078-0432</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Clinical cancer research</title><title level="j" type="abbreviated">Clin. cancer res.</title><idno type="ISSN">1078-0432</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis</term><term>Antineoplastic agent</term><term>Breast cancer</term><term>Correlation</term><term>FcγR receptor</term><term>Genetic variability</term><term>Genotype</term><term>Human</term><term>Immunoglobulin receptor</term><term>Patient</term><term>Polymorphism</term><term>Prognosis</term><term>Trastuzumab</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Analyse</term><term>Récepteur FcγR</term><term>Récepteur immunoglobuline</term><term>Polymorphisme</term><term>Variabilité génétique</term><term>Génotype</term><term>Corrélation</term><term>Pronostic</term><term>Trastuzumab</term><term>Traitement</term><term>Cancer du sein</term><term>Homme</term><term>Malade</term><term>Anticancéreux</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose: The mechanisms by which trastuzumab imparts clinical benefit remain incompletely understood. Antibody-dependent cellular cytotoxicity via interactions with Fcγ receptors (FcγR) on leukocytes may contribute to its antitumor effects. Single-nucleotide polymorphisms (SNP) in FCGR3A and FCGR2A genes lead to amino acid substitutions at positions 158 and 131, respectively, and affect binding of antibodies to FcγR such that 158V/V and 131H/H bind with highest affinity. This study aimed to determine whether high-affinity SNPs are associated with disease-free survival (DFS) among patients with HER2-positive nonmetastatic breast cancer. Experimental Design: Genomic DNA was isolated from 1,286 patients enrolled in a trial of adjuvant trastuzumab-based chemotherapy. Genotyping was conducted using Sanger sequencing and Sequenom mass spectrometry. Results: Patient samples (N = 1,189) were successfully genotyped for FCGR3A and 1,218 for FCGR2A. Compared with the overall results of the BCIRG006 study, in the subset of patients genotyped in this analysis, a less robust improvement in DFS was observed for the trastuzumab arms than control arm (HR, 0.842; P = 0.1925). When stratified for prognostic features, the HR in favor of trastuzumab was consistent with that of the overall study (HR, 0.74; P = 0.036). No correlation between DFS and FCGR3A/2A genotypes was seen for trastuzumab-treated patients (158V/V vs. V/F vs. F/F, P = 0.98; 131 H/H vs. H/R vs. R/R, P = 0.76; 158V/V and/or 131H/H vs. others, P = 0.67). Conclusion: This analysis evaluating the association between FCGR3A/2A genotypes and trastuzumab efficacy in HER2-positive breast cancer did not show a correlation between FCGR3A-V/F and FCGR2A-H/R SNPs and DFS in patients treated with trastuzumab.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Belgique</li><li>Canada</li><li>Espagne</li><li>France</li><li>Irlande (pays)</li><li>Pologne</li><li>États-Unis</li></country><region><li>Alabama</li><li>Californie</li><li>Communauté de Madrid</li><li>Pennsylvanie</li><li>Texas</li><li>Virginie</li><li>Île-de-France</li></region><settlement><li>Los Angeles</li><li>Madrid</li><li>Paris</li></settlement></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Hurvitz, Sara A" sort="Hurvitz, Sara A" uniqKey="Hurvitz S" first="Sara A." last="Hurvitz">Sara A. Hurvitz</name></region><name sortKey="Betting, David J" sort="Betting, David J" uniqKey="Betting D" first="David J." last="Betting">David J. Betting</name><name sortKey="Brufsky, Adam" sort="Brufsky, Adam" uniqKey="Brufsky A" first="Adam" last="Brufsky">Adam Brufsky</name><name sortKey="Falkson, Carla" sort="Falkson, Carla" uniqKey="Falkson C" first="Carla" last="Falkson">Carla Falkson</name><name sortKey="Marathe, Omkar" sort="Marathe, Omkar" uniqKey="Marathe O" first="Omkar" last="Marathe">Omkar Marathe</name><name sortKey="Robert, Nicholas J" sort="Robert, Nicholas J" uniqKey="Robert N" first="Nicholas J." last="Robert">Nicholas J. Robert</name><name sortKey="Seshagiri, Somasekar" sort="Seshagiri, Somasekar" uniqKey="Seshagiri S" first="Somasekar" last="Seshagiri">Somasekar Seshagiri</name><name sortKey="Slamon, Dennis J" sort="Slamon, Dennis J" uniqKey="Slamon D" first="Dennis J." last="Slamon">Dennis J. Slamon</name><name sortKey="Sliwkowski, Mark X" sort="Sliwkowski, Mark X" uniqKey="Sliwkowski M" first="Mark X." last="Sliwkowski">Mark X. Sliwkowski</name><name sortKey="Stern, Howard M" sort="Stern, Howard M" uniqKey="Stern H" first="Howard M." last="Stern">Howard M. Stern</name><name sortKey="Stinson, Jeremy" sort="Stinson, Jeremy" uniqKey="Stinson J" first="Jeremy" last="Stinson">Jeremy Stinson</name><name sortKey="Timmerman, John M" sort="Timmerman, John M" uniqKey="Timmerman J" first="John M." last="Timmerman">John M. Timmerman</name><name sortKey="Valero, Vicente" sort="Valero, Vicente" uniqKey="Valero V" first="Vicente" last="Valero">Vicente Valero</name><name sortKey="Ying Zhao" sort="Ying Zhao" uniqKey="Ying Zhao" last="Ying Zhao">YING ZHAO</name></country><country name="Belgique"><noRegion><name sortKey="Quinaux, Emmanuel" sort="Quinaux, Emmanuel" uniqKey="Quinaux E" first="Emmanuel" last="Quinaux">Emmanuel Quinaux</name></noRegion><name sortKey="Buyse, Marc" sort="Buyse, Marc" uniqKey="Buyse M" first="Marc" last="Buyse">Marc Buyse</name></country><country name="Canada"><noRegion><name sortKey="Mackey, John" sort="Mackey, John" uniqKey="Mackey J" first="John" last="Mackey">John Mackey</name></noRegion><name sortKey="Damaraju, Sambasivarao" sort="Damaraju, Sambasivarao" uniqKey="Damaraju S" first="Sambasivarao" last="Damaraju">Sambasivarao Damaraju</name><name sortKey="Driga, Adrian" sort="Driga, Adrian" uniqKey="Driga A" first="Adrian" last="Driga">Adrian Driga</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Crown, John" sort="Crown, John" uniqKey="Crown J" first="John" last="Crown">John Crown</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Pienkowski, Tadeusz" sort="Pienkowski, Tadeusz" uniqKey="Pienkowski T" first="Tadeusz" last="Pienkowski">Tadeusz Pienkowski</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Eiermann, Wolfgang" sort="Eiermann, Wolfgang" uniqKey="Eiermann W" first="Wolfgang" last="Eiermann">Wolfgang Eiermann</name></noRegion></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Martin, Miguel" sort="Martin, Miguel" uniqKey="Martin M" first="Miguel" last="Martin">Miguel Martin</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Bee, Valerie" sort="Bee, Valerie" uniqKey="Bee V" first="Valerie" last="Bee">Valerie Bee</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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